Encala results

Encala has been clinically proven to help people with cystic fibrosis (CF) and exocrine pancreatic insufficiency (EPI) improve overall fat and nutrient absorption

In a National Institutes of Health study, 110 people with CF and EPI added Encala to their meals, beverages, or snacks for one year.
Results showed that Encala helped people with CF and EPI absorb fat and other essential nutrients, allowing them to reach and maintain
weight, height, and body mass index (BMI) targets in a healthy way.

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Who was studied

Children and adolescents 5 to 18 years of age with CF, currently taking pancreatic enzyme replacement therapy (PERT), and with mild to moderate lung disease were recruited from 10 CF centers.

How they were studied

For 1 year:

  • Patients 5 to 11 years of age ate food and/or drank beverages mixed with 2 servings/day of either Encala or an active placebo
  • Patients 12 to 18 years of age ate food and/or drank beverages mixed with 3 servings/day of either Encala or an active placebo

What the study measured

Encala’s effectiveness was measured by improvement in overall fat absorption, weight, height, and BMI increases.

Encala significantly improves overall fat absorption as measured by change in stool coefficient of fat absorption (CFA)

Encala was found to be effective and clinically proven to:

  • Improve overall fat absorption
  • Increase weight, height, and BMI
  • Increase blood levels of essential fatty acids, fat-soluble vitamins, and choline. Choline is an essential nutrient that helps improve general health in patients with CF, among other benefits
Encala was found to be safe. In the course of the study, Encala was found to be safe. It was also well-tolerated, which means it did not result in any significant side effects in the patients who received Encala.

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